Human CBLB Recombinant protein (His tag)

Human CBLB Recombinant protein (His tag)

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E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. {PubMed:10022120, PubMed:10086340, PubMed:11087752, PubMed:11526404, PubMed:14661060, PubMed:20525694}.

E3 ubiquitin-protein ligase CBL-B

RNF56

B8K284

CBLB; RNF56; Nbla00127

E. coli

A DNA sequence encoding the human CBLB (NP_001308715.1) 29-380 aa was fused with the polyhistidine tag

Human

Not tested.