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Human CANT1 (Fc Tag) recombinant protein

Cat.#: 503300

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Product Information

  • Product Name
    Human CANT1 (Fc Tag) recombinant protein
  • Documents
  • Description
    CANT1(calcium activated nucleotidase 1) belongs to the apyrase family. Apyrase is a calcium-activated plasma membrane-bound enzyme (magnesium can also activate it) (EC 3.6.1.5) that catalyses the hydrolysis of ATP to yield AMP and inorganic phosphate. Two isoenzymes are found in commercial preparations from S. tuberosum. One with a higher ratio of substrate selectivity for ATP: ADP and another with no selectivity. It can also act on ADP and other nucleoside triphosphates and diphosphates with the general reaction being NTP -> NDP + Pi -> NMP + 2Pi. The salivary apyrases of blood-feeding arthropods are nucleotide hydrolysing enzymes are implicated in the inhibition of host platelet aggregation through the hydrolysis of extracellular adenosine diphosphate. CANT1 functions as a calcium-dependent nucleotidase with a preference for UDP. Defects in CANT1 are the cause of desbuquois dysplasia.
  • Protein name
    Soluble calcium-activated nucleotidase 1
  • Protein short names
    CA2+-DEPENDENT ENDOPLASMIC RETICULUM NUCLEOSIDE DIPHOSPHATASE; MICROMELIC DWARFISM WITH VERTEBRAL AND METAPHYSEAL ABNORMALITIES AND ADVANCED CARPOTARSAL OSSIFICATION; RP23-394O9.5; HOMOLOG (C. LECTULARIUS); SCAN-1; SOLUBLE CA-ACTIVATED NUCLEOTIDASE; ENTPD8; APY1H; PUTATIVE MAPK-ACTIVATING PROTEIN PM09; APYRASE HOMOLOG; APYRASE 1; D11BWG0554E; SOLUBLE CALCIUM-ACTIVATED NUCLEOTIDASE SCAN-1; PUTATIVE NF-KAPPA-B-ACTIVATING PROTEIN 107; SOLUBLE CALCIUM-ACTIVATED NUCLEOTIDASE 1; DBQD; SHAPY; ISOZYME 1; SCAN1; 5830420C20RIK
  • Uniprot ID
    Q8WVQ1
  • Gene Name
    CANT1; SHAPY
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human CANT1 (Q8WVQ1-1) (Gly80-Ile401) was expressed,with the fused Fc region of human IgG1 at the N-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human CANT1/Fc is a disulfide-linked homodimer. The reduced monomer comprises 582 amino acids and has a predicted molecular mass of 64.3 kDa. The apparent molecular mass of the protein is approximately 65 kDa in SDS-PAGE under reducing conditions due to glycosylation.
  • Purity
    > 90 % as determined by SDS-PAGE
  • Validations

    Human CANT1 Protein (Fc Tag) SDS-PAGE

    Human CANT1 Protein (Fc Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"