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  • Human CALCOCO1 Recombinant protein (GST tag)

Human CALCOCO1 Recombinant protein (GST tag)

Cat.#: 506154

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Product Information

  • Product Name
    Human CALCOCO1 Recombinant protein (GST tag)
  • Documents
  • Description
    Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1-mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions (By similarity). In association with CCAR1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {UniProtKB:Q8CGU1, PubMed:24245781}.; Seems to enhance inorganic pyrphosphatase thus activating phosphogluomutase (PMG). Probably functions as component of the calphoglin complex, which is involved in linking cellular metabolism (phosphate and glucose metabolism) with other core functions including protein synthesis and degradation, calcium signaling and cell growth. {Ref.1}.
  • Protein name
    Calcium-binding and coiled-coil domain-containing protein 1
  • Protein short names
    KIAA1536
  • Uniprot ID
    Q9P1Z2
  • Gene Name
    CALCOCO1; KIAA1536; PP13275; UNQ2436/PRO4996
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    341-691 aa encoded by NM_020898 was inserted into PGEX-4T vector
  • Protein Species
    Human
  • Activity
    Not tested.
  • Validations

    Recombinant human CALCOCO1 SDS-PAGE

    Recombinant human CALCOCO1 SDS-PAGE

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