Human C8G (His tag) recombinant protein

Human C8G (His tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Complement component C8 is a constituent of the membrane attack complex, C8 alpha, C8 beta and C8G. C8G is a secreted protein and comsists a disulfide-linked C8 alpha-gamma heterodimer and a non-covalently associated C8 beta chain. C8 alpha and C8 beta play an important role in complement-mediated bacterial killing together.C8 is involved in the formation of Membrane Attack Complex on bacterial cell membranes. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol. Patients lacking C8 are susceptible to certain bacterial infections.

complement C8 gamma chain(C8G)

P07360

E. coli

A DNA sequence encoding the Human C8G Gln21-Arg202 is expressed with a 6His tag at the N-terminus.

Human

>95% as determined by SDS-PAGE.