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Product Name
Human C1orf86 Recombinant protein (His tag)
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Description
Component of the Fanconi anemia (FA) complex required to recruit the FA complex to DNA interstrand cross-links (ICLs) and promote ICLs repair. Following DNA damage recognizes and binds 'Lys-63'-linked ubiquitin generated by RNF8 at ICLs and recruits other components of the FA complex. Promotes translesion synthesis via interaction with REV1. {PubMed:22266823, PubMed:22343915, PubMed:22396592, PubMed:22705371}.
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Protein name
Fanconi anemia core complex-associated protein 20
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Protein short names
C1orf86
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Uniprot ID
Q6NZ36
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Gene Name
FAAP20; C1orf86; FP7162
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
1-195 aa encoded by BC103992 was inserted into PET28a vector
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Protein Species
Human
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Activity
Not tested.
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Validations
Recombinant human C1orf86 SDS-PAGE
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