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Product Name
Human C1orf170 Recombinant protein (His tag)
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Description
Regulates the expression of selective PPARGC1A/B and ESRRA/B/G target genes with roles in glucose and lipid metabolism, energy transfer, contractile function, muscle mitochondrial biogenesis and oxidative capacity. Required for the efficient induction of MT-CO2, MT-CO3, COX4I1, TFB1M, TFB2M, POLRMT and SIRT3 by PPARGC1A. Positively regulates the PPARGC1A/ESRRG-induced expression of CKMT2, TNNI3 and SLC2A4 and negatively regulates the PPARGC1A/ESRRG-induced expression of PDK4. {UniProtKB:Q149B8}.
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Protein name
PGC-1 and ERR-induced regulator in muscle protein 1
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Protein short names
C1orf170
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Uniprot ID
Q5SV97
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Gene Name
PERM1; C1orf170
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
1-58 aa encoded by NM_032722 was inserted into PET28a vector
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Protein Species
Human
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Activity
Not tested.
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Validations
Recombinant human C1orf170 SDS-PAGE
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