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Product Name
Human C14orf169 Recombinant protein (His tag)
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Description
Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216'. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation (By similarity). May also play a role in ribosome biogenesis and in the replication or remodeling of certain heterochromatic region. Participates in MYC-induced transcriptional activation. {, PubMed:14742713, PubMed:17308053, PubMed:23103944}.
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Protein name
Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66
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Protein short names
C14orf169; MAPJD
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Uniprot ID
A0A0A8K8C0
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Gene Name
NO66; C14orf169; MAPJD
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human NO66 (NP_078920.2) 296-640 aa was fused with the polyhistidine tag
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Protein Species
Human
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Activity
Not tested.
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Validations
Recombinant human C14orf169 SDS-PAGE
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