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Product Name
Human Biglycan (His Tag) recombinant protein
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Description
Biglycan, also known as PG-S1 and BGN, is a a small leucine-rich repeat proteoglycan (SLRP). It can be detected in a variety of extracellular matrix tissues, including bone, cartilage and tendon. Biglycan consists of a protein core containing leucine-rich repeat regions and two glycosaminoglycan (GAG) chains consisting of either chondroitin sulfate (CS) or dermatan sulfate (DS). Non-glycanated forms of biglycan (no GAG chains) increase with age in human articular cartilage. Biglycan interacts with collagen, both via the core protein and GAG chains. Biglycan plays a role in the mineralisation of bone. Biglycan core protein binds to the growth factors BMP-4 and influences its bioactivity.
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Protein short names
DERMATAN SULPHATE PROTEOGLYCAN I; DSPG1; BIGLYCAN; PG-S1; BONE/CARTILAGE PROTEOGLYCAN I; BGN; RP23-95K12.7; BG; BIGLYCAN PROTEOGLYCAN; SMALL; PGI; SLRR1A
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Uniprot ID
P21810
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human BGN (NP_001702.1) (Asp38-Lys368) was expressed with a polyhistidine tag at the C-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human BGN consists of 342 amino acids and predicts a molecular mass of 38.7 kDa.
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Purity
> 95 % as determined by SDS-PAGE.
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Validations
Human Biglycan / BGN Protein (His Tag)
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