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Product Name
Human BCOR Recombinant protein (His tag)
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Description
Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2). {PubMed:10898795, PubMed:15004558, PubMed:18280243, PubMed:19578371, PubMed:23911289}.
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Protein name
BCL-6 corepressor
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Protein short names
KIAA1575
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Uniprot ID
H9A532
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Gene Name
BCOR; KIAA1575
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human BCOR (XP_005272675.1) 1396-1755 aa was fused with the polyhistidine tag
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Protein Species
Human
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Activity
Not tested.
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Validations
Recombinant human BCOR SDS-PAGE
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