Human BCL2L11/BIM (His tag) recombinant protein

Human BCL2L11/BIM (His tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

BIML is one of several splice variants of BIM, a proapoptotic protein belonging to the BH-3 domain-only subgroup of Bcl-2 family members. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. BIML is thought to promote apoptosis by binding and inhibiting the activity of anti-apoptotic Bcl-2 family members, thereby inducing the release of cytochrome c from mitochondria. BIML is normally sequestered in an inactive conformation from anti-apoptotic Bcl-2 family members through binding to the microtubule-associated dynein motor complex. Certain apoptotic stimuli release BIML from microtubules to neutralize anti-apoptotic Bcl-2 family members, allowing for the initiation of apoptosis.

BCL2 like 11(BCL2L11)

BIM

O43521-2

E. coli

A DNA sequence encoding the Human BCL2L11/BIM Met1-Arg120 is expressed with a 6His tag at the N-terminus.

Human

>95% as determined by SDS-PAGE.