Human AURKA Recombinant protein (GST tag)

Human AURKA Recombinant protein (GST tag)

• DataSheet
• Material Safety Data Sheets (MSDS)

Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis. {PubMed:11039908, PubMed:11551964, PubMed:12390251, PubMed:13678582, PubMed:14523000, PubMed:14702041, PubMed:14990569, PubMed:15128871, PubMed:15147269, PubMed:15987997, PubMed:17125279, PubMed:17360485, PubMed:17604723, PubMed:18056443, PubMed:18615013, PubMed:19351716, PubMed:19357306, PubMed:19668197, PubMed:19812038, PubMed:20643351, PubMed:9606188}.

Aurora kinase A

AIK; AIRK1; ARK1; AURA; AYK1; BTAK; IAK1; STK15; STK6

O14965

AURKA; AIK; AIRK1; ARK1; AURA; AYK1; BTAK; IAK1; STK15; STK6

E. coli

A DNA sequence encoding the human AURKA (NP_001411348.1) 142-371 aa was fused with the N-terminal GST tag

Human

Not tested.