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Product Name
Human ARHGAP22 Recombinant protein (His tag)
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Description
Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter (By similarity).
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Protein name
Rho GTPase-activating protein 22
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Protein short names
RHOGAP2
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Uniprot ID
A0A2X0SFC0
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Gene Name
ARHGAP22; RHOGAP2
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human ARHGAP22 (XP_011538305.1) 528-662 aa was fused with the polyhistidine tag
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Protein Species
Human
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Activity
Not tested.
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Validations
Recombinant human ARHGAP22 SDS-PAGE
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