Human ANGPTL4 / angiopoietin-like protein 4 (His Tag)

Human ANGPTL4 / angiopoietin-like protein 4 (His Tag)

• DataSheet
• Material Safety Data Sheets (MSDS)

ANGPTL4, also known as ANGPTL2, is a protein with hypoxia-induced expression in endothelial cells. It contains 1 fibrinogen C-terminal domain and is expressed at high levels in the placenta, heart, liver, muscle, pancreas and lung but expressed poorly in the brain and kidney. ANGPTL4 inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. It may act as a regulator of angiogenesis and modulate tumorigenesis. It inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. It may also exert a protective function on endothelial cells through an endocrine action. ANGPTL4 is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation.

Angiopoietin-related protein 4

ARP4; FIBRINOGEN/ANGIOPOIETIN-RELATED PROTEIN; FASTING-INDUCED ADIPOSE FACTOR; PGAR; HARP; ANGPTL2; FIAF; ANGIOPOIETIN-RELATED PROTEIN 4; ANGIOPOIETIN-LIKE PROTEIN 4; HFARP; BK89; NL2; MAJOR HISTOCOMPATIBILITY COMPLEX REGION NG27; HEPATIC FIBRINOGEN/ANGIOPOIETIN-RELATED PROTEIN; UNQ171; NG27; SECRETED PROTEIN BK89; PPARG ANGIOPOIETIN RELATED PROTEIN; TGQTL; 425O18-1; PP1158; PGARG; HEPATIC ANGIOPOIETIN-RELATED PROTEIN; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR (PPAR) GAMMA INDUCED ANGIOPOIETIN-RELATED PROTEIN

Q9BY76

ANGPTL4; ARP4; HFARP; PGAR; PP1158; PSEC0166; UNQ171/PRO197

Human Cells

A DNA sequence encoding the human ANGPTL4 (Q9BY76) (Pro166-Ser406) was expressed with an N-terminal polyhistidine tag.

Human

The recombinant human ANGPTL4 comprises 261 amino acids and has a predicted molecular mass of 29.5 kDa. The apparent molecular mass of the protein is approximately 35 kDa in SDS-PAGE under reducing conditions due to glycosylation.

> 95 % as determined by SDS-PAGE