Mouse ANGPTL4 / angiopoietin-like protein 4 (His Tag)

Mouse ANGPTL4 / angiopoietin-like protein 4 (His Tag)

• DataSheet
• Material Safety Data Sheets (MSDS)

Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorigenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity (By similarity). In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation.

Angiopoietin-related protein 4

ANGPTL2; HARP; FIAF; ARP4; FIBRINOGEN/ANGIOPOIETIN-RELATED PROTEIN; FASTING-INDUCED ADIPOSE FACTOR; PGAR; BK89; NL2; HEPATIC FIBRINOGEN/ANGIOPOIETIN-RELATED PROTEIN; MAJOR HISTOCOMPATIBILITY COMPLEX REGION NG27; ANGIOPOIETIN-RELATED PROTEIN 4; ANGIOPOIETIN-LIKE PROTEIN 4; HFARP; NG27; SECRETED PROTEIN BK89; PPARG ANGIOPOIETIN RELATED PROTEIN; UNQ171; TGQTL; 425O18-1; PP1158; PGARG; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR (PPAR) GAMMA INDUCED ANGIOPOIETIN-RELATED PROTEIN; HEPATIC ANGIOPOIETIN-RELATED PROTEIN

Q9Z1P8

Angptl4; Farp; Fiaf; Ng27

Human Cells

A DNA sequence encoding the mouse ANGPTL4 (Q9Z1P8) (Lys167-Ser410) was expressed with a polyhistidine tag at the N-terminus.

Mouse

The recombinant mouse ANGPTL4 consists of 264 amino acids and predicts a molecular mass of 29.9 KDa. It migrates as an approximately 38-45 KDa band in SDS-PAGE under reducing conditions due to glycosylation.

> 95 % as determined by SDS-PAGE