Human AMFR Recombinant protein (His tag)

Human AMFR Recombinant protein (His tag)

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E3 ubiquitin-protein ligase that mediates the polyubiquitination of a number of proteins such as CD3D, CYP3A4, CFTR and APOB for proteasomal degradation. Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG complex at the ER membrane and initiating ubiquitination of HMGCR. The ubiquitinated HMGCR is then released from the ER by the complex into the cytosol for subsequent destruction. Also acts as a scaffold protein to assemble a complex that couples ubiquitination, retranslocation and deglycosylation. Mediates tumor invasion and metastasis as a receptor for the GPI/autocrine motility factor. {PubMed:10456327, PubMed:11724934, PubMed:16168377, PubMed:19103148}.

E3 ubiquitin-protein ligase AMFR

RNF45

Q9UKV5

AMFR; RNF45

E. coli

A DNA sequence encoding the human AMFR (NP_001135.3) 301-643 aa was fused with the polyhistidine tag

Human

Not tested.