Human AMFR Recombinant protein (His tag)

Cat.#: 505218

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Product Information

  • Product Name
    Human AMFR Recombinant protein (His tag)
  • Documents
  • Description
    E3 ubiquitin-protein ligase that mediates the polyubiquitination of a number of proteins such as CD3D, CYP3A4, CFTR and APOB for proteasomal degradation. Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG complex at the ER membrane and initiating ubiquitination of HMGCR. The ubiquitinated HMGCR is then released from the ER by the complex into the cytosol for subsequent destruction. Also acts as a scaffold protein to assemble a complex that couples ubiquitination, retranslocation and deglycosylation. Mediates tumor invasion and metastasis as a receptor for the GPI/autocrine motility factor. {PubMed:10456327, PubMed:11724934, PubMed:16168377, PubMed:19103148}.
  • Protein name
    E3 ubiquitin-protein ligase AMFR
  • Protein short names
    RNF45
  • Uniprot ID
    Q9UKV5
  • Gene Name
    AMFR; RNF45
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human AMFR (NP_001135.3) 301-643 aa was fused with the polyhistidine tag
  • Protein Species
    Human
  • Activity
    Not tested.
  • Validations

    Recombinant human AMFR SDS-PAGE

    Recombinant human AMFR SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"