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Product Name
Human AKR1C4/CHDR (His tag) recombinant protein
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Description
Aldo-Keto Reductase 1C4/AKR1C4 is a member of the aldo/keto reductase family that consists of more than 40 known enzymes and proteins. AKR1C4 has highly expressed in Liver. It can catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. AKR1C4 catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-α-Androstan-3-α,17-β-diol (3-α-diol). In addition, AKR1C4 also has some 20-α-Hydroxysteroid Dehydrogenase activity.
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Protein name
aldo-keto reductase family 1 member C4(AKR1C4)
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Protein short names
CHDR
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Uniprot ID
P17516
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the Human AKR1C4/CHDR Met1-Tyr323 is expressed with a 6His tag at the N-terminus.
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Protein Species
Human
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Purity
>95% as determined by SDS-PAGE.
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Validations
Human AKR1C4/CHDR (His tag) recombinant protein
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