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Product Name
Human AKR1C4/3-alpha-HSD1 (His Tag) recombinant protein
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Description
Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol). Also has some 20-alpha-hydroxysteroid dehydrogenase activity. The biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route.
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Protein name
Aldo-keto reductase family 1 member C4
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Protein short names
DIHYDRODIOL DEHYDROGENASE 4; AKR1C4; 3-ALPHA-HSD1; C11; CHDR; HAKRA; ALDO-KETO REDUCTASE FAMILY 1; TYPE I 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE; CDR; CHLORDECONE REDUCTASE; ALDO-KETO REDUCTASE FAMILY 1 MEMBER C4; MEMBER C4; DD-4; DIHYDRODIOL DEHYDROGENASE ISOZYME DD4; DD4; 3-ALPHA-HSD; 3-ALPHA HYDROXYSTEROID DEHYDROGENASE; TYPE I
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Uniprot ID
P17516
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Gene Name
AKR1C4; CHDR
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human AKR1C4 (AAH20744.1) (Met1-Tyr323) was expressed with a polyhistidine tag at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human AKR1C4 consists of 341 amino acids and predicts a molecular mass of 39.4 KDa. It migrates as an approximately 35-40 KDa band in SDS-PAGE under reducing conditions.
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Purity
> 85 % as determined by SDS-PAGE
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Validations
Human AKR1C4 Protein (His Tag) SDS-PAGE
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