Human AIFM1/AIF/PDCD8 (His tag) recombinant protein

Cat.#: 518910

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Product Information

  • Product Name
    Human AIFM1/AIF/PDCD8 (His tag) recombinant protein
  • Documents
  • Description
    Apoptosis-Inducing Factor 1, Mitochondrial (AIFM1) is a flavoprotein essential for nuclear disassembly in apoptotic cells that is found in the mitochondrial intermembrane space in healthy cells. During apoptosis, it is translocated from the mitochondria to the nucleus to function as a proapoptotic factor in a caspase-independent pathway, while in normal mitochondria, it functions as an antiapoptotic factor via its oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces parthanatos i.e., caspase-independent fragmentation of chromosomal DNA. AIFM1 interacts with EIF3G, and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. It binds to DNA in a sequence-independent manner and plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells.
  • Protein name
    apoptosis inducing factor, mitochondria associated 1(AIFM1)
  • Protein short names
    AIF; PDCD8
  • Uniprot ID
    O95831
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    A DNA sequence encoding the Human AIFM1/AIF/PDCD8 Glu121-Asp613 is expressed with a 6His tag at the N-terminus.
  • Protein Species
    Human
  • Purity
    >95% as determined by SDS-PAGE.
  • Validations

    Human AIFM1/AIF/PDCD8 (His tag) recombinant protein

    Human AIFM1/AIF/PDCD8 (His tag) recombinant protein

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"