Human AIFM1/AIF/PDCD8 (His tag) recombinant protein

Human AIFM1/AIF/PDCD8 (His tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Apoptosis-Inducing Factor 1, Mitochondrial (AIFM1) is a flavoprotein essential for nuclear disassembly in apoptotic cells that is found in the mitochondrial intermembrane space in healthy cells. During apoptosis, it is translocated from the mitochondria to the nucleus to function as a proapoptotic factor in a caspase-independent pathway, while in normal mitochondria, it functions as an antiapoptotic factor via its oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces parthanatos i.e., caspase-independent fragmentation of chromosomal DNA. AIFM1 interacts with EIF3G, and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. It binds to DNA in a sequence-independent manner and plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells.

apoptosis inducing factor, mitochondria associated 1(AIFM1)

AIF; PDCD8

O95831

E. coli

A DNA sequence encoding the Human AIFM1/AIF/PDCD8 Glu121-Asp613 is expressed with a 6His tag at the N-terminus.

Human

>95% as determined by SDS-PAGE.