Anti-AIF (8H1) Mouse antibody

Anti-AIF (8H1) Mouse antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

AIF (8H1) Mouse monoclonal antibody

WB, ICC/IF

Human

AIFM1; AIFM1_HUMAN; Apoptosis inducing factor 1 antibody; mitochondrial; Apoptosis inducing factor; Apoptosis inducing factor antibody; mitochondrion associated antibody; 1; Apoptosis-inducing factor 1; CMTX4; COWCK; COXPD6; Harlequin; Hq; mAIF; MGC111425; MGC5706; mitochondrial; N antibody

Mouse IgG2a

Antigen: Purified recombinant human AIF protein fragments expressed in E.coli.

Monoclonal

Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.03% Proclin300 and 50% glycerol.

Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

Swiss-Prot Acc.O95831.Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. In contrast, functions as an antiapoptotic factor in normal mitochondria via its NADH oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G,and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner.