Human ACMSD Recombinant protein (His tag)

Human ACMSD Recombinant protein (His tag)

• DataSheet
• Material Safety Data Sheets (MSDS)

Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway. {PubMed:19843166}.

2-amino-3-carboxymuconate-6-semialdehyde decarboxylase

Q8TDX5

ACMSD

E. coli

A DNA sequence encoding the human ACMSD (NP_612199.2) 105-310 aa was fused with the polyhistidine tag

Human

Not tested.