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HSP90 antibody

Cat.#: 107268

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Product Information

  • Product Name
    HSP90 antibody
  • Documents
  • Description
    HSP90 Mouse Monoclonal antibody. Positive WB detected in Y79 cells. Positive FC detected in K-562 cells. Observed molecular weight by Western-blot: 85-90 kDa
  • Tested applications
    ELISA, WB, FC
  • Species reactivity
    Human; other species not tested.
  • Alternative names
    FLJ31884 antibody; Heat shOCk 86 kDa antibody; HSP 86 antibody; HSP86 antibody; Hsp89 antibody; HSP89A antibody; HSP90 antibody; HSP90A antibody; HSP90AA1 antibody; HSP90N antibody; HSPC1 antibody; HSPCA antibody; HSPCAL1 antibody; HSPCAL4 antibody; HSPN antibody; LAP2 antibody
  • Immunogen
    Human HSP90 Recombinant protein (GST tag)
  • Isotype
    Mouse IgG2a
  • Preparation
    This antibody was obtained by immunization of HSP90 recombinant protein (Accession Number: BC023006). Purification method: Protein A purified.
  • Clonality
    Monoclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:1000-1:10000

  • Validations

    Y79 cells were subjected to SDS PAGE followed by western blot with Catalog No:107268(HSP90 Antibody) at dilution of 1:4000

    Y79 cells were subjected to SDS PAGE followed by western blot with Catalog No:107268(HSP90 Antibody) at dilution of 1:4000

    1X10^6 K-562 cells were stained with 0.2ug HSP90 antibody (Catalog No:107268, red) and control antibody (blue). Fixed with 90% MeOH blocked with 3% BSA (30 min). Alexa Fluor 488-congugated AffiniPure Goat Anti-Mouse IgG(H+L) with dilution 1:1000.

    1X10^6 K-562 cells were stained with 0.2ug HSP90 antibody (Catalog No:107268, red) and control antibody (blue). Fixed with 90% MeOH blocked with 3% BSA (30 min). Alexa Fluor 488-congugated AffiniPure Goat Anti-Mouse IgG(H+L) with dilution 1:1000.

  • Background
    HSP90, encoded by HSP90AA1, is a constitutively and ubiquitously expressed molecular chaperone that is crucial for the stability and function of many proteins. HSP90 provides chaperoning activity for client proteins; many of them are members of oncogenic pathways, indicating its implication in tumor malignancy. HSP90 mainly resides in the cytosol, while it can also be released to the extracellular space. Secreted Hsp90 is a C-terminal truncated form. It has been reported that the level of plasma Hsp90 is positively correlated with tumor malignancy in clinical cancer patients, and can be a promising diagnostic marker for tumor malignancy in clinical application.
  • References
    • Ulanova A, Gritsyna Y, Vikhlyantsev I. Isoform composition and gene expression of thick and thin filament proteins in striated muscles of mice after 30-day space flight. BioMed research international. 2015:104735. 2015.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"