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Product Name
HSD3B7 antibody
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Description
HSD3B7 Rabbit Polyclonal antibody. Positive IHC detected in human pancreas cancer tissue, human kidney tissue, human liver tissue. Positive WB detected in mouse liver tissue. Observed molecular weight by Western-blot: 36 kDa
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Tested applications
ELISA, WB, IHC
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Species reactivity
Human, Mouse; other species not tested.
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Alternative names
3 beta HSD VII antibody; C(27) 3 beta HSD antibody; HSD3B7 antibody; PFIC4 antibody; SDR11E3 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of HSD3B7 recombinant protein (Accession Number: NM_025193). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
IHC: 1:20-1:200
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Validations
mouse liver tissue were subjected to SDS PAGE followed by western blot with Catalog No:111553(HSD3B7 antibody) at dilution of 1:500
Immunohistochemical of paraffin-embedded human pancreas cancer using Catalog No:111553(HSD3B7 antibody) at dilution of 1:50 (under 10x lens)
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Background
HSD3B7(3 beta-hydroxysteroid dehydrogenase type 7) is also named as 3-beta-HSD VII,C(27) 3-beta-HSD and belongs to the 3-beta-HSD family. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids and HSD VII is active against four 7-alpha-hydroxylated sterols. This enzyme is expressed predominantly in the liver(PMID:11067870). Defects in HSD3B7 are the cause of congenital bile acid synthesis defect type 1 (CBAS1). It has 2 isoforms produced by alternative splicing.
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