HRPT2 antibody

HRPT2 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

HRPT2 Rabbit Polyclonal antibody. Positive IHC detected in human breast cancer tissue. Positive IF detected in Hela cells. Positive IP detected in mouse testis tissue. Positive WB detected in human lung tissue, human heart tissue, mouse testis tissue. Observed molecular weight by Western-blot: 61 kDa

ELISA, WB, IHC, IF, IP

Human,Mouse,Rat; other species not tested.

C1orf28 antibody; CDC73 antibody; FLJ23316 antibody; HPT JT antibody; HRPT2 antibody; Hyperparathyroidism 2 protein antibody; Parafibromin antibody

Rabbit IgG

This antibody was obtained by immunization of HRPT2 recombinant protein (Accession Number: BC014351). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

Parafibromin is a product of the hyperparathyroidism-jaw tumor syndrome gene HRPT2/CDC73, a putative tumor suppressor gene recently implicated in the autosomal dominant hyperparathyroidism-jaw tumor familial cancer syndrome, sporadic parathyroid cancer, and a minority of families with isolated hyperparathyroidism (PMID: 15580289). Defects in CDC73 are causes of hyperparathyroidism type 1 (HRPT1) and hyperparathyroidism type 2 (HRPT2) as well as parathyroid carcinoma (PRTC) (PMID: 12434154). Tumor suppressor parafibromin to the transcription elongation and RNA processing pathway as a PAF1 complex- and RNA polymerase II-bound protein (PMID: 15923622). Besides, parafibromin is also involved in post-transcriptional control pathways (PMID: 16116486). Recent report has revealed that pathogenic mutation, such as CDC73 gene mutation, is able to affect histone monoubiquitination (PMID: 22021426).