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Product Name
HNRNPH1 antibody
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Description
HNRNPH1 Rabbit Polyclonal antibody. Positive WB detected in mouse brain tissue, HeLa cells, mouse embryonic stem cells. Positive IHC detected in human cervical cancer tissue. Observed molecular weight by Western-blot: 49 kDa
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Tested applications
ELISA, WB, IHC
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
DKFZp686A15170 antibody; hnRNP H antibody; hnRNPH antibody; HNRNPH1 antibody; HNRPH antibody; HNRPH1 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of HNRNPH1 recombinant protein (Accession Number: XM_017009416). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IHC: 1:20-1:200
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Validations
mouse brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:111507(HNRNPH1 antibody) at dilution of 1:500
Immunohistochemical of paraffin-embedded human cervical cancer using Catalog No:111507(HNRNPH1 antibody) at dilution of 1:50 (under 10x lens)
Immunohistochemical of paraffin-embedded human cervical cancer using Catalog No:111507(HNRNPH1 antibody) at dilution of 1:50 (under 40x lens)
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Background
The heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. HNRNPH1 is one component of hnRNP complex and mediates pre-mRNA alternative splicing regulation [PMID:11003644]. Together with CUGBP1, it inhibits IR pre-mRNA exon 11 inclusion in myoblast [PMID: 16946708].
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References
- Neumann M, Valori CF, Ansorge O. Transportin 1 accumulates specifically with FET proteins but no other transportin cargos in FTLD-FUS and is absent in FUS inclusions in ALS with FUS mutations. Acta neuropathologica. 124(5):705-16. 2012.
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