HNMT antibody

Cat.#: 111498

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Product Information

  • Product Name
    HNMT antibody
  • Documents
  • Description
    HNMT Rabbit Polyclonal antibody. Positive WB detected in human liver tissue, mouse liver tissue. Positive IF detected in MCF-7 cells. Positive IHC detected in human lymphoma tissue. Observed molecular weight by Western-blot: 33 kDa
  • Tested applications
    ELISA, WB, IHC, IF
  • Species reactivity
    Human, Mouse, Rat; other species not tested.
  • Alternative names
    histamine N methyltransferase antibody; HMT antibody; HNMT antibody; HNMT S1 antibody; HNMT S2 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of HNMT recombinant protein (Accession Number: NM_006895). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:500-1:5000

    IHC: 1:20-1:200

    IF: 1:10-1:100

  • Validations

    human liver tissue were subjected to SDS PAGE followed by western blot with Catalog No:111498(HNMT antibody) at dilution of 1:400

    human liver tissue were subjected to SDS PAGE followed by western blot with Catalog No:111498(HNMT antibody) at dilution of 1:400

    Immunohistochemical of paraffin-embedded human lymphoma using Catalog No:111498(HNMT antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemical of paraffin-embedded human lymphoma using Catalog No:111498(HNMT antibody) at dilution of 1:50 (under 10x lens)

    Immunofluorescent analysis of MCF-7 cells using Catalog No:111498(HNMT Antibody) at dilution of 1:25 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

    Immunofluorescent analysis of MCF-7 cells using Catalog No:111498(HNMT Antibody) at dilution of 1:25 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

  • Background
    HNMT, a histamine-metabolizing enzyme, inactivates histamine by N-methylation. It plays an important role in degrading histamine and in regulating the airway response to histamine. HNMT in human astrocytes play a role in the regulation of extraneuronal histamine concentration and the activities of histaminergic neurons.
  • References
    • Yoshikawa T, Naganuma F, Iida T. Molecular mechanism of histamine clearance by primary human astrocytes. Glia. 61(6):905-16. 2013.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"