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Product Name
HMGN2 antibody
- Documents
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Description
HMGN2 Rabbit Polyclonal antibody. Positive WB detected in Jurkat cells, HeLa cells, HepG2 cells, HL-60 cells, K-562 cells. Positive IHC detected in human prostate cancer tissue, human cervical cancer tissue. Observed molecular weight by Western-blot: 18-20 kDa
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Tested applications
ELISA, WB, IHC
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Species reactivity
Human; other species not tested.
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Alternative names
HMG17 antibody; HMGN2 antibody
- Immunogen
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of HMGN2 recombinant protein (Accession Number: NM_005517). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
IHC: 1:20-1:200
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Validations
Jurkat cells were subjected to SDS PAGE followed by western blot with Catalog No:111487(HMGN2 antibody) at dilution of 1:600
Immunohistochemical of paraffin-embedded human prostate cancer using Catalog No:111487(HMGN2 antibody) at dilution of 1:50 (under 10x lens)
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Background
HMGN2 is a highly conserved nucleosomal protein which may involve in unfolding higher-order chromatin structure and facilitating the transcriptional activation of mammalian genes. It is the most abundant, ubiquitous and evolutionarily conserved nonhistione proteins found in the nuclei of higher eukaryotes. It binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer.
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References
- Su L, Hu A, Luo Y, Zhou W, Zhang P, Feng Y. HMGN2, a new anti-tumor effector molecule of CD8⁺ T cells. Molecular cancer. 13:178. 2014.
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