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Product Name
Human SUV420H2 (His & GST Tag) recombinant protein
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Description
Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity).
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Protein name
Histone-lysine N-methyltransferase SUV420H2
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Protein short names
PP7130; SUV4-20H2; KMT5C; FLJ98627; BC024816; MGC36471; SUV420H2; MGC2705
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Uniprot ID
Q86Y97
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Gene Name
SUV420H2; KMT5C; PP7130
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the amino acid sequence (Gly 2-Leu 280) of human SUV420H2 (NP_116090.2) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human SUV420H2/GST chimera consists of 516 amino acids and has a calculated molecular mass of 60 kDa as estimated in SDS-PAGE under reducing conditions.
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Purity
> 80 % as determined by SDS-PAGE
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Validations
Human SUV420H2 Protein (His & GST Tag) SDS-PAGE
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