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Product Name
Human RBBP4/RBAP48 (His Tag) recombinant protein
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Description
Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.
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Protein name
Histone-binding protein RBBP4
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Protein short names
RBAP48; MRBAP48; NURF55; RP23-391E6.3; CAF-1 SUBUNIT C; CAF-1 P48 SUBUNIT; CAF-I 48 KDA SUBUNIT; RBBP4; CAF-I P48; RBBP-4
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Uniprot ID
Q09028
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Gene Name
RBBP4; RBAP48
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Source/Expression Host
Baculovirus-Insect Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the full length of human RBBP4 (NP_005601.1) (Met 1-Ser 425) was expressed, with a polyhistidine tag at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human RBBP4 consists of 443 amino acids and predicts a molecular mass of 50 kDa as estimated in SDS-PAGE under reducing conditions.
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Purity
> 90 % as determined by SDS-PAGE
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Validations
Human RBBP4 / RBAP48 Protein (His Tag) SDS-PAGE
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