HIP1-Specific antibody

HIP1-Specific antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

HIP1-Specific Rabbit Polyclonal antibody. Positive WB detected in COLO 320 cells, HEK-293 cells, mouse colon tissue. Positive IP detected in HEK-293 cells. Positive IHC detected in human brain tissue, human colon cancer tissue, human prostate cancer tissue. Observed molecular weight by Western-blot: 116 kDa

ELISA, WB, IHC, IP

Human,Mouse,Rat; other species not tested.

HIP 1 antibody; HIP I antibody; HIP1 antibody; ILWEQ antibody

Rabbit IgG

This antibody was obtained by immunization of Peptide (Accession Number: NM_005338). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

HIP1 Belongs to the SLA2 family. HIP1 plays a role in clathrin-mediated endocytosis and trafficking. It is involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. It enhances androgen receptor (AR)-mediated transcription. HIP1 may act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway. It binds 3-phosphoinositides (via ENTH domain). HIP1 may act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. HIP1 plays a functional role in the cell filament networks. It is required for differentiation, proliferation, and/or survival of somatic and germline progenitors. A chromosomal aberration involving HIP1 is found in a form of chronic myelomonocytic leukemia (CMML). The antibody is specific to HIP1.