H5N1 HA (His Tag) recombinant protein

H5N1 HA (His Tag) recombinant protein

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Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.

Hemagglutinin

H-RASIDX; HAMSV; SPNA-1; C-BAS/HAS; HA; CTLO; C-HA-RAS1; SPH; C-H-RAS; SPNA1; AI451697; IHJ; NMF4; P21RAS; HRAS1; RASH1; AF093576

G2U0T8

HA

Human Cells

A DNA sequence encoding the Influenza A virus (A/Hubei/1/2010(H5N1)) hemagglutinin (AEO89181.1) (Met1-Arg339), termed as HA1, was expressed with a polyhistidine tag at the C-terminus.

H5N1

The recombinant HA1 subunit of the Influenza A virus hemagglutinin (A/Hubei/1/2010(H5N1)) consists 334 amino acids and predicts a molecular mass of 37.9 kDa.

> 95 % as determined by SDS-PAGE.