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Product Name
HECTD3 antibody
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Description
HECTD3 Rabbit Polyclonal antibody. Positive WB detected in MCF7 cells. Observed molecular weight by Western-blot: 97kd
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Tested applications
ELISA, WB
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Species reactivity
Human, Mouse; other species not tested.
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Alternative names
FLJ21156 antibody; FLJ31983 antibody; HECT domain containing 3 antibody; HECTD3 antibody; RP11 69J16.1 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of HECTD3 recombinant protein (Accession Number: BC019105). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
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Validations
MCF7 cells were subjected to SDS PAGE followed by western blot with Catalog No:111398(HECTD3 antibody) at dilution of 1:400
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Background
HECTD3(HECT domain-containing protein 3) may be involved in the regulation of mitotic metaphase/anaphase transition. It can specifically ubiquitinate TRIOBP and target it for proteasomal degradation and it can also mediates the ubiquitination of STX8. HECTD3 is a new oncogenic E3 ligase in human prostate cancer.( Li Y, etc. 2008) HECTD3 may facilitate cell cycle progression via regulating ubiquitination and degradation of Tara(PMID:18194665). It has 2 isoforms produced by alternative splicing.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"