HDAC6-specific antibody

HDAC6-specific antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

HDAC6-specific Rabbit Polyclonal antibody. Positive WB detected in MCF7 cells, HT-1080 cells. Positive IHC detected in mouse brain tissue. Observed molecular weight by Western-blot: 130 kDa

ELISA, WB, IHC

Human,Mouse,Rat; other species not tested.

FLJ16239 antibody; HD6 antibody; HDAC6 antibody; histone deacetylase 6 antibody; JM21 antibody; KIAA0901 antibody

Rabbit IgG

This antibody was obtained by immunization of Peptide (Accession Number: NM_001321231). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

Histone deacetylases(HDAC) are a class of enzymes that remove the acetyl groups from the lysine residues leading to the formation of a condensed and transcriptionally silenced chromatin. At least 4 classes of HDAC were identified. HDAC6 is a member of the class II mammalian histone deacetylases. It possesses two separate putative catalytic domains. Both catalytic domains are fully functional HDACs and contribute independently to the overall activity of HDAC6 protein. A very potent NES is present at the amino-terminus of HDAC6, which was found to play an important role in regulating the shuttling of HDAC6 protein between cytoplasm and nucleus. The shuttling process may be a critical regulatory mechanism of HDAC6 function. The expression of HDAC6 is tightly linked to the state of cell differentiation. HDAC6 may participate in coordinating expression of a group of genes involved in the remodelling of chromatin during cell differentiation. This antibody is specific to HDAC6. It does not cross react with other HDACs.

• He M, Zhang B, Wei X. HDAC4/5-HMGB1 signalling mediated by NADPH oxidase activity contributes to cerebral ischaemia/reperfusion injury. Journal of cellular and molecular medicine. 17(4):531-42. 2013.