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Product Name
HCLS1 antibody
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Description
HCLS1 Rabbit Polyclonal antibody. Positive WB detected in Jurkat cells. Positive IHC detected in human tonsillitis tissue. Observed molecular weight by Western-blot: 75 kDa
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Tested applications
ELISA, WB, IHC
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Species reactivity
Human; other species not tested.
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Alternative names
CTTNL antibody; HCLS1 antibody; HS1 antibody; LckBP1 antibody; p75 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of HCLS1 recombinant protein (Accession Number: NM_005335). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IHC: 1:20-1:200
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Validations
Jurkat cells were subjected to SDS PAGE followed by western blot with Catalog No:111283(HCLS1 Antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human tonsillitis tissue slide using Catalog No:111283(HCLS1 Antibody) at dilution of 1:50 (under 40x lens)
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Background
Hematopoietic cell-specific Lyn substrate 1 (HS1, HCLS1, LckBP1 and p75) is a 75-kDa intracellular protein expressed in cells of lymphohemopoietic origin. It was originally identified in B-lymphocytes as a major substrate of B-cell receptor (BCR)-induced phosphorylation after antigen (Ag) stimulation. It’s a substrate of the antigen receptor-coupled tyrosine kinase. HCLS1 plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells.
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