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Product Name
Human GDF-15 (Fc Tag) recombinant protein
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Description
Growth-differentiation factor 15 (GDF15), also known as MIC-1, is a secreted member of the transforming growth factor (TGF)-β superfamily, as a novel antihypertrophic regulatory factor in the heart. GDF-15 / GDF15 is not expressed in the normal adult heart but is induced in response to conditions that promote hypertrophy and dilated cardiomyopathy and it is expressed highly in liver. GDF-15 / GDF15 has a role in regulating inflammatory and apoptotic pathways in injured tissues and during disease processes. GDF-15 / GDF15 is synthesized as precursor molecules that are processed at a dibasic cleavage site to release C-terminal domains containing a characteristic motif of 7 conserved cysteines in the mature protein. GDF-15 / GDF15 overexpression arising from an expanded erythroid compartment contributes to iron overload in thalassemia syndromes by inhibiting hepcidin expression.
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Protein name
Growth/differentiation factor 15
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Protein short names
GDF-15; GDF15; PTGFB; NAG-1; MIC1; PDF; SBF; MIC-1; PLAB
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Uniprot ID
Q99988
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Gene Name
GDF15; MIC1; PDF; PLAB; PTGFB
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the mature form of human GDF15 (NP_004855.2) (Ala 197-Ile 308) was expressed with the fused Fc region of human IgG1 at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human Fc/GDF15 is a disulfide-linked homodimeric protein. The reduced monomer consists of 370 amino acids and has a predicted molecular mass of 40.6 kDa. rhGDF15/Fc monomer migrates as an approximately 44 kDa protein in SDS-PAGE under reducing conditions.
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Purity
> 95 % as determined by SDS-PAGE
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Validations
Human GDF-15 Protein (Fc Tag) SDS-PAGE
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