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Product Name
Anti-GDF15 Rabbit antibody
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Description
GDF15 Rabbit polyclonal antibody
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Tested applications
WB
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Species reactivity
Human
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Alternative names
PDF; MIC1; PLAB; MIC-1; NAG-1; PTGFB; GDF-15 antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: A synthetic peptide of human GDF15
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Clonality
Polyclonal
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Formulation
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage instructions
Store at -20°C. Stable for 12 months from date of receipt.
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Applications
WB: 1/1000
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Validations
Western blot detection of GDF15 in Hela cell lysates using GDF15 Rabbit pAb(1:1000 diluted).Predicted band size:34kDa.Observed band size:34kDa.
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Background
Swiss-Prot Acc.Q99988.Regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099, PubMed:23468844, PubMed:29046435). Binds to its receptor, GFRAL, and activates GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099). It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which contitutes part of the 'emergency circuit' that shapes feeding responses to stressful conditions (PubMed:28953886). On hepatocytes, inhibits growth hormone signaling .
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"