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GRIA3 Polyclonal Antibody

Cat.#: 160771

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Product Information

  • Product Name
    GRIA3 Polyclonal Antibody
  • Documents
  • Description
    Polyclonal antibody to GRIA3
  • Tested applications
    WB, IHC, IF
  • Species reactivity
    Human, Mouse, Rat
  • Alternative names
    GRIA3 antibody; GLUR-C antibody; GLUR-K3 antibody; GLUR3 antibody; GLURC antibody; GluA3 antibody; MRX94 antibody; glutamate receptor 3 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: Recombinant fusion protein containing a sequence corresponding to amino acids 200-490 of human GRIA3 (NP_000819.3).
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • Storage instructions
    Store at -20℃. Avoid freeze / thaw cycles.
  • Applications
    WB 1:500 - 1:2000
    IHC 1:50 - 1:200
    IF 1:50 - 1:200
  • Validations

    Western blot - GRIA3 Polyclonal Antibody

    Western blot - GRIA3 Polyclonal Antibody

    Western blot analysis of extracts of various cell lines, using GRIA3 antibody at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.

    Immunofluorescence - GRIA3 Polyclonal Antibody

    Immunofluorescence - GRIA3 Polyclonal Antibody

    Immunofluorescence analysis of U2OS cells using GRIA3 antibody . Blue: DAPI for nuclear staining.

  • Background
    Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"