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Product Name
GRHPR antibody
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Description
GRHPR Rabbit Polyclonal antibody. Positive WB detected in mouse liver tissue, human liver tissue, L02 cells, MCF-7 cells. Positive IHC detected in human liver tissue, human ovary tumor tissue. Observed molecular weight by Western-blot: 36 kDa
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Tested applications
ELISA, WB, IHC
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Species reactivity
Human, Mouse; other species not tested.
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Alternative names
GLXR antibody; GLYD antibody; GRHPR antibody; PH2 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of GRHPR recombinant protein (Accession Number: NM_012203). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
IHC: 1:20-1:200
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Validations
mouse liver tissue were subjected to SDS PAGE followed by western blot with Catalog No:111204(GRHPR Antibody) at dilution of 1:600
Immunohistochemistry of paraffin-embedded human liver tissue slide using Catalog No:111204(GRHPR Antibody) at dilution of 1:200 (under 10x lens)
Immunohistochemistry of paraffin-embedded human liver tissue slide using Catalog No:111204(GRHPR Antibody) at dilution of 1:200 (under 40x lens)
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Background
GRHPR(Glyoxylate reductase/hydroxypyruvate reductase) is also named as GLXR and belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. The GRHPR gene encodes a predicted 328-amino acid protein with a calculated molecular mass of 35.5 kD. It has glyoxylate reductase (GR), hydroxypyruvate reductase (HPR) and D-glycerate dehydrogenase (DGDH) activities(PMID:16597637). Defects in GRHPR are the cause of hyperoxaluria primary type 2 (HP2)(PMID: 10484776). It can exsit as a homodimer(PMID:16756993).
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