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Product Name
Mouse GREM1 (His Tag) recombinant protein
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Description
Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as BMP a antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner. Acts as inhibitor of monocyte chemotaxis.
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Protein name
Gremlin-1
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Protein short names
PROLIFERATION-INDUCING GENE 2; BMP ANTAGONIST 1; DRM; INCREASED IN HIGH GLUCOSE-2; LD; IHG-2; CYSTEINE KNOT SUPERFAMILY 1; CYSTEINE KNOT SUPERFAMILY; GREMLIN 1-LIKE PROTEIN; CRAC1; GREMLIN 1; GREMLIN; DAND2; DOWN-REGULATED IN MOS-TRANSFORMED CELLS PROTEIN; HMPS; C15DUPQ; DOWN-REGULATED IN V-MOS-TRANSFORMED CELLS; DUP15Q; GREMLIN-1; CRCS4; RP23-178K16.1; HMPS1; GREM; CKTSF1B1; DAN DOMAIN FAMILY MEMBER 2; PIG2; INCREASED IN HIGH GLUCOSE PROTEIN 2; CELL PROLIFERATION-INDUCING GENE 2 PROTEIN; MPSH; MGC126660; HOMOLOG
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Uniprot ID
O70326
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Gene Name
Grem1; Cktsf1b1; Drm
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Source/Expression Host
Baculovirus-Insect Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the mouse GREM1 (O70326) (Met1-Asp184) was fused with a polyhistidine tag at the C-terminus.
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Protein Species
Mouse
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Molecular weight
The recombinant mouse GREM1 consists of 171 amino acids and has a calculated molecular mass of 19.7 kDa. The recombinant protein migrates as an approximately 25 kDa band in SDS-PAGE under reducing conditions.
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Purity
> 97 % as determined by SDS-PAGE
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Activity
Measured by its ability to inhibit recombinant human BMP4 induced alkaline phosphatase production by MC3T3-E1 cells.
The ED50 for this effect is typically 1-7 μg/mL in the presence of 50 ng/mL of recombinant human BMP4. -
Validations
Mouse Gremlin 1 / GREM1 Protein (His Tag) SDS-PAGE
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