-
Product Name
GREM1 Polyclonal Antibody
- Documents
-
Description
Polyclonal antibody to GREM1
-
Tested applications
WB
-
Species reactivity
Human
-
Alternative names
GREM1 antibody; C15DUPq antibody; CKTSF1B1 antibody; CRAC1 antibody; CRCS4 antibody; DAND2 antibody; DRM antibody; DUP15q antibody; GREMLIN antibody; HMPS antibody; HMPS1 antibody; IHG-2 antibody; MPSH antibody; PIG2 antibody; gremlin-1 antibody
-
Isotype
Rabbit IgG
-
Preparation
Antigen: Recombinant fusion protein containing a sequence corresponding to amino acids 44-143 of human GREM1 (NP_001178252.1).
-
Clonality
Polyclonal
-
Formulation
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
-
Storage instructions
Store at -20℃. Avoid freeze / thaw cycles.
-
Applications
WB 1:500 - 1:2000
-
Validations
Western blot - GREM1 Polyclonal Antibody
Western blot analysis of extracts of various cell lines, using GREM1 Antibody at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit .Exposure time: 20s.
-
Background
Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner (By similarity). Antagonist of BMP2; inhibits BMP2-mediated differentiation of osteoblasts (in vitro). Acts as inhibitor of monocyte chemotaxis. Can inhibit the growth or viability of normal cells but not transformed cells when is overexpressed (By similarity).
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"