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Granzyme A antibody

Cat.#: 111160

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Product Information

  • Product Name
    Granzyme A antibody
  • Documents
  • Description
    Granzyme A Rabbit Polyclonal antibody. Positive IHC detected in human lymphoma tissue. Positive WB detected in Jurkat cells, mouse kidney tissue. Observed molecular weight by Western-blot: 60kd
  • Tested applications
    ELISA, WB, IHC
  • Species reactivity
    Human, Mouse; other species not tested.
  • Alternative names
    CTL tryptase antibody; CTLA3 antibody; Fragmentin 1 antibody; Granzyme 1 antibody; Granzyme A antibody; GZMA antibody; H factor antibody; Hanukkah factor antibody; HFSP antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of Granzyme A recombinant protein (Accession Number: NM_006144). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:200-1:2000

    IHC: 1:20-1:200

  • Validations

    Jurkat cells were subjected to SDS PAGE followed by western blot with Catalog No:111160(GZMA antibody) at dilution of 1:600

    Jurkat cells were subjected to SDS PAGE followed by western blot with Catalog No:111160(GZMA antibody) at dilution of 1:600

    Immunohistochemical of paraffin-embedded human lymphoma using Catalog No:111160(GZMA antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemical of paraffin-embedded human lymphoma using Catalog No:111160(GZMA antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemical of paraffin-embedded human lymphoma using Catalog No:111160(GZMA antibody) at dilution of 1:50 (under 40x lens)

    Immunohistochemical of paraffin-embedded human lymphoma using Catalog No:111160(GZMA antibody) at dilution of 1:50 (under 40x lens)

  • Background
    Granzyme A is necessary for target cell lysis in cell-mediated immune responses. It activates mitochondrial outer membrane permeabilization- and caspase-independent cell death pathways by cleaving the mitochondrial complex I component NDUFS3after lys56. This protein has 2 isoforms produced by alternative promoter usage.
  • References
    • Chen CY, Xie QM, Xue Y. Characterization of cytotoxicity-related gene expression in response to virulent Marek's disease virus infection in the bursa of Fabricius. Research in veterinary science. 94(3):496-503. 2013.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"