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Product Name
GRAMD4 antibody
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Description
GRAMD4 Rabbit Polyclonal antibody. Positive WB detected in PC-3 cells. Observed molecular weight by Western-blot: 66, 140 kDa
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Tested applications
ELISA, WB
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Species reactivity
Human; other species not tested.
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Alternative names
dA59H18.1 antibody; Death inducing protein antibody; DIP antibody; dJ439F8.1 antibody; GRAM domain containing 4 antibody; GRAMD4 antibody; KIAA0767 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of GRAMD4 recombinant protein (Accession Number: XM_047441209). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:1000
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Validations
PC-3 cells were subjected to SDS PAGE followed by western blot with Catalog No:111156(GRAMD4 Antibody) at dilution of 1:300
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Background
GRAMD4 also termed as Death inducing protein is a 578 amino-acid protein, which contains 1 GRAM domain. GRAMD4 as a multi-pass membrane protein localizes in the Mitochondrion membrane. Overexpression of GRAMD4 results in a strong apoptotic response involving caspase-3 activation and cleavage of poly(ADP-ribose)-polymerase. GRAMD4 is expressed in lung and in primary lung squamous cell carcinoma (LSCC) and shows up-regulation in mitochondria by E2F-1 after addition of 4-hydroxytamoxifen. This evidence suggests that GRAMD4 may be a potential target for cancer therapies.
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