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GPX7 antibody

Cat.#: 111151

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Special Price 239.0 USD

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Product Information

  • Product Name
    GPX7 antibody
  • Documents
  • Description
    GPX7 Rabbit Polyclonal antibody. Positive WB detected in human liver tissue, human brain tissue, Transfected HEK-293 cells. Positive IHC detected in human liver cancer tissue, human brain tissue. Observed molecular weight by Western-blot: 21 kDa
  • Tested applications
    ELISA, WB, IHC
  • Species reactivity
    Human; other species not tested.
  • Alternative names
    CL683 antibody; FLJ14777 antibody; glutathione peroxidase 7 antibody; GPx 7 antibody; GPX6 antibody; GPX7 antibody; GSHPx 7 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of GPX7 recombinant protein (Accession Number: NM_015696). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:500-1:5000

    IHC: 1:20-1:200

  • Validations

    human liver tissue were subjected to SDS PAGE followed by western blot with Catalog No:111151(GPX7 antibody) at dilution of 1:1000

    human liver tissue were subjected to SDS PAGE followed by western blot with Catalog No:111151(GPX7 antibody) at dilution of 1:1000

    Immunohistochemical of paraffin-embedded human liver cancer using Catalog No:111151(GPX7 antibody) at dilution of 1:100 (under 10x lens)

    Immunohistochemical of paraffin-embedded human liver cancer using Catalog No:111151(GPX7 antibody) at dilution of 1:100 (under 10x lens)

    Immunohistochemical of paraffin-embedded human liver cancer using Catalog No:111151(GPX7 antibody) at dilution of 1:100 (under 40x lens)

    Immunohistochemical of paraffin-embedded human liver cancer using Catalog No:111151(GPX7 antibody) at dilution of 1:100 (under 40x lens)

  • Background
    GPX7(Glutathione peroxidase 7) is also named as GPX6,CL683,GSHPx-7 and belongs to the glutathione peroxidase family.It shares approximately 45% amino acid sequence with other GPX family members.Because GPX7 expression protected cells from acidic bile acidinduced DNA damage, it may protect oesophageal epithelial cells from acidic bile acid-induced apoptosis(PMID:22157330).
  • References
    • Peng DF, Hu TL, Soutto M, Belkhiri A, El-Rifai W. Loss of glutathione peroxidase 7 promotes TNF-α-induced NF-κB activation in Barrett's carcinogenesis. Carcinogenesis. 35(7):1620-8. 2014.
    • Peng DF, Hu TL, Soutto M, Belkhiri A, El-Rifai W. Glutathione Peroxidase 7 Suppresses Bile Salt-Induced Expression of Pro-Inflammatory Cytokines in Barrett's Carcinogenesis. Journal of Cancer. 5(7):510-7. 2014.
    • Peng D, Belkhiri A, Hu T. Glutathione peroxidase 7 protects against oxidative DNA damage in oesophageal cells. Gut. 61(9):1250-60. 2012.
    • Peng D, Hu T, Soutto M, Belkhiri A, Zaika A, El-Rifai W. Glutathione peroxidase 7 has potential tumour suppressor functions that are silenced by location-specific methylation in oesophageal adenocarcinoma. Gut. 63(4):540-51. 2014.
    • Chang YC, Yu YH, Shew JY. Deficiency of NPGPx, an oxidative stress sensor, leads to obesity in mice and human. EMBO molecular medicine. 5(8):1165-79. 2013.
    • Ramming T, Hansen HG, Nagata K, Ellgaard L, Appenzeller-Herzog C. GPx8 peroxidase prevents leakage of H2O2 from the endoplasmic reticulum. Free radical biology & medicine. 70:106-16. 2014.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"