-
Product Name
GPR132 antibody
- Documents
-
Description
GPR132 Rabbit Polyclonal antibody. Positive WB detected in mouse spleen tissue. Positive IHC detected in human kidney tissue.
-
Tested applications
ELISA, IHC, WB
-
Species reactivity
Human,Mouse,Rat; other species not tested.
-
Alternative names
G protein coupled receptor 132 antibody; G2 accumulation protein antibody; G2A antibody; GPR132 antibody
-
Isotype
Rabbit IgG
-
Preparation
This antibody was obtained by immunization of GPR132 recombinant protein (Accession Number: NM_001278694). Purification method: Antigen affinity purified.
-
Clonality
Polyclonal
-
Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
-
Storage instructions
Store at -20℃. DO NOT ALIQUOT
-
Applications
Recommended Dilution:
WB: 1:200-1:1000
IHC: 1:20-1:200
-
Validations
mouse spleen tissue were subjected to SDS PAGE followed by western blot with Catalog No:111110(GPR132 Antibody) at dilution of 1:300
Immunohistochemical of paraffin-embedded human kidney using Catalog No:111110(GPR132 antibody) at dilution of 1:50 (under 40x lens)
Immunohistochemical of paraffin-embedded human kidney using Catalog No:111110(GPR132 antibody) at dilution of 1:50 (under 10x lens)
-
Background
GPR132, also known as G2A (G2 accumulation protein), belongs to the G-protein coupled receptor (GPCR) 1 family. GPR132 is a DNA damage and stress inducible GPCR that blocks cells in G2/M. It functions at the G2/M checkpoint to delay mitosis and may serve as a mechanism for T and B cells and other cell types to slow their proliferation and repair damaged DNA to ensure proper replication (PMID: 9770487). Lysophosphatidylcholine (LPC) is a high affinity ligand for GPR132 (PMID: 15653487).
-
References
- Fujita K, Sugiyama A, Otoshi K. Partial characterization of proapoptotic action of biliary deteriorated lipids on biliary epithelial cells in pancreaticobiliary diseases. Journal of hepato-biliary-pancreatic sciences. 21(3):212-8. 2014.
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"