-
Product Name
GPM6A antibody
- Documents
-
Description
GPM6A Rabbit Polyclonal antibody. Positive IP detected in mouse brain tissue. Positive WB detected in mouse retina tissue, rat brain tissue. Positive IHC detected in human brain tissue. Observed molecular weight by Western-blot: 31 kDa
-
Tested applications
ELISA, WB, IP, IHC
-
Species reactivity
Human, Mouse, Rat; other species not tested.
-
Alternative names
glycoprotein M6A antibody; GPM6 antibody; GPM6A antibody; M6A antibody
-
Isotype
Rabbit IgG
-
Preparation
This antibody was obtained by immunization of GPM6A recombinant protein (Accession Number: NM_201591). Purification method: Antigen affinity purified.
-
Clonality
Polyclonal
-
Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
-
Storage instructions
Store at -20℃. DO NOT ALIQUOT
-
Applications
Recommended Dilution:
WB: 1:200-1:2000
IP: 1:200-1:2000
IHC: 1:20-1:200
-
Validations
mouse retina tissue were subjected to SDS PAGE followed by western blot with Catalog No:111066(GPM6A antibody) at dilution of 1:600
IP Result of anti-GPM6A (IP:Catalog No:111066, 3ug; Detection:Catalog No:111066 1:800) with mouse brain tissue lysate 6500ug.
Immunohistochemical of paraffin-embedded human brain using Catalog No:111066(GPM6A antibody) at dilution of 1:50 (under 10x lens)
Immunohistochemical of paraffin-embedded human brain using Catalog No:111066(GPM6A antibody) at dilution of 1:50 (under 40x lens)
-
Background
Glycoprotein M6A (GPM6A, or M6A) is known as a multi-pass transmembrane protein and an abundant cell surface protein on neurons in the central nervous system (CNS). M6A belongs to the myelin proteolipid protein family and is involved in neuronal differentiation, including differentiation and migration of neuronal stem cell. M6A is identified as a retinal membrane protein that is strongly expressed at embryonic stages. In mouse adult retina, M6A plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation via regulation of MAPK and Src signaling pathways.
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"