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  • GnRH peptide

GnRH peptide

Not For Human Use, Lab Use Only.

Cat.#: 316495

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Special Price 151.80 USD

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Product Information

  • Product Name
    GnRH peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    pEHWSYGLRPG, pE=Pyr
  • Sequence
    H-pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-OH
  • Length (aa)
    10
  • Peptide Purity (HPLC)
    96.02%
  • Molecular Formula
    C55H76N16O15
  • Molecular Weight
    1200.57
  • Source
    Synthetic
  • Form
    Powder
  • Description

    Gonadotropin-releasing hormone (GnRH) is a decapeptide neurohormone originally isolated from mammalian hypothalamus. Its amino acid sequence is pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2. This peptide is characterized by a conserved N-terminal tetrapeptide (Glu-His-Trp-Ser) and C-terminal dipeptide (Pro-Gly) across most known isoforms. In the cephalochordate amphioxus Branchiostoma lanceolatum, a peptide with an identical sequence and molecular mass to mammalian GnRH has been identified. The highest concentrations of this peptide are localized in the anterior body region and exhibit seasonal variation, with a peak coinciding with gonadal preparation for spawning.

    GnRH represents an evolutionarily ancient signaling molecule, with its origins traceable to the base of the chordate lineage. Its presence in amphioxus, an invertebrate chordate, suggests a fundamental and conserved role in neuroendocrine signaling related to reproductive processes that predates the evolution of the vertebrate pituitary gland.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Chambery A, Parente A, Topo E, Garcia-Fernàndez J, D'Aniello S Characterization and putative role of a type I gonadotropin-releasing hormone in the cephalochordate amphioxus Endocrinology 2009 Feb;150(2):812-20
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"