Glypican 3 antibody

Glypican 3 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Glypican 3 Rabbit Polyclonal antibody. Positive WB detected in Jurkat cells. Observed molecular weight by Western-blot: 66 kDa

ELISA, WB

Human,Mouse,Rat; other species not tested.

DGSX antibody; Glypican 3 antibody; GPC3 antibody; GTR2 2 antibody; Intestinal protein OCI 5 antibody; MXR7 antibody; OCI 5 antibody; OCI5 antibody; SDYS antibody; SGB antibody; SGBS antibody; SGBS1 antibody

Rabbit IgG

This antibody was obtained by immunization of Glypican 3 recombinant protein (Accession Number: NM_004484). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

Glypicans (GPCs) are a family of glycosylphosphatidylinositol (GPI)-anchored heparan sulphate proteoglycans (HSPGs) that may play a role in the control of cell division and growth regulation. In mammals, there are six GPCs (GPC1 to GPC6), all of which have a similar core-protein size of approx. 60 kDa and the clustering of glycosaminoglycan attachment site near the C-terminus. They are tethered to the cell surface by GPI linkages, which can be cleaved by endogenous phospholipases, thus releasing the protein. Glypican 3 (GPC3) is highly expressed in many tissues during development and plays an important role in the regulation of embryonic growth (PMID: 22467855). Loss-of-function mutations of GPC3 result in the Simpson-Golabi-Behmel overgrowth syndrome (SGBS), and Gpc-3 null mice display developmental overgrowth (PMID: 8589713; 18477453). In hepatocellular carcinoma (HCC), the overexpression of GPC3 has been demonstrated to be a reliable diagnostic indicator (PMID: 19212669; 22706665).

• Qi XH, Wu D, Cui HX. Silencing of the glypican-3 gene affects the biological behavior of human hepatocellular carcinoma cells. Molecular medicine reports. 10(6):3177-84. 2014.