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Rat GDNF (His Tag) recombinant protein

Cat.#: 501013

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Product Information

  • Product Name
    Rat GDNF (His Tag) recombinant protein
  • Documents
  • Description
    Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. May also modulate local neuronal effects in distal regions of the motor neuron.
  • Protein name
    Glial cell line-derived neurotrophic factor
  • Protein short names
    ATF1; MGDNF; ATF; HFB1-GDNF; ATF2; ASTROCYTE-DERIVED TROPHIC FACTOR; AI385739; NEUROTROPHIC FACTOR; HSCR3; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR
  • Uniprot ID
    Q07731
  • Gene Name
    Gdnf
  • Source/Expression Host
    Baculovirus-Insect Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the mature form of rat GDNF (Q07731-1) (Ser78-Ile211) was expressed,with a polyhistide tag at the N-terminus.
  • Protein Species
    Rat
  • Molecular weight
    The recombinant rat GDNF consists of 150 amino acids and predicts a molecular mass of 17.1 KDa. It migrates as an approximately 20 KDa band in SDS-PAGE under reducing conditions.
  • Purity
    > 95 % as determined by SDS-PAGE
  • Activity
    1. Measured in a cell proliferation assay using SH‑SY5Y human neuroblastoma cells. The ED50 for this effect is typically 10-50 ng/mL in the presence of Recombinant Rat GFR alpha‑1/GDNF R alpha‑1 His Chimera.
    2. Immobilized rat His-GDNF (78-211) at 10 μg/ml (100 μl/well) can bind rat GFRA1-Fc (cat:503822), The EC50 of rat GFRA1-Fc (cat:503822) is 20-46.6 ng/ml.
  • Validations

    Rat GDNF Protein (His Tag) SDS-PAGE

    Rat GDNF Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"