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Product Name
GCHFR antibody
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Description
GCHFR Rabbit Polyclonal antibody. Positive IHC detected in human cervix. Positive WB detected in mouse skin tissue. Observed molecular weight by Western-blot: 10kd
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Tested applications
ELISA, WB, IHC
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Species reactivity
human, mouse, rat; other species not tested.
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Alternative names
GCHFR antibody; HsT16933 antibody; GFRP antibody; P35 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of Peptide (Accession Number: NM_005258). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IHC: 1:20-1:200
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Validations
mouse skin tissue were subjected to SDS PAGE followed by western blot with Catalog No:110903(GCHFR antibody) at dilution of 1:500
Immunohistochemical of paraffin-embedded human cervix using Catalog No:110903(GCHFR antibody) at dilution of 1:100 (under 10x lens)
Immunohistochemical of paraffin-embedded human cervix using Catalog No:110903(GCHFR antibody) at dilution of 1:100 (under 40x lens)
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Background
GCHFR,also named as p35 and GFRP, belongs to the GFRP family. GCHFR mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine.
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References
- Pathak R, Pawar SA, Fu Q. Characterization of transgenic Gfrp knock-in mice: implications for tetrahydrobiopterin in modulation of normal tissue radiation responses. Antioxidants & redox signaling. 20(9):1436-46. 2014.
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