GAP43 antibody

GAP43 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

GAP43 Rabbit Polyclonal antibody. Positive IP detected in mouse brain tissue. Positive WB detected in mouse brain tissue, rat brain tissue, rat lung tissue. Observed molecular weight by Western-blot: 43 kDa

ELISA, WB, IP

Human,Mouse,Rat; other species not tested.

Axonal membrane protein GAP 43 antibody; B 50 antibody; GAP43 antibody; growth assOCiated protein 43 antibody; Neural phosphoprotein B 50 antibody; Neuromodulin antibody; PP46 antibody

Rabbit IgG

This antibody was obtained by immunization of GAP43 recombinant protein (Accession Number: NM_002045). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

The neuronal growth-associated protein GAP43 is also known as neuromodulin, B-50, P-57, F1 and pp46. Deficiency of GAP43 in mice results in death early in the postnatal period. GAP43 is one of the main substrates for protein kinase C in the brain. GAP43 is an intracellular growth-associated protein that appears to assist neuronal pathfinding and branching during development and regeneration, and may contribute to presynaptic membrane changes in the adult, leading to the neurotransmitter release, endocytosis and synaptic vesicle recycling, long-term potentiation, spatial memory formation, and learning. The predicated molecular weight of about 25 kDa is much lower than the apparent observed molecular weight of 43 kDa on SDS-PAGE gels, and this occurs because the highly charged nature of GAP43 causes it to bind less than the average amount of SDS per amino acid, and because the protein has an elongated structure.

• Yin F, Meng C, Lu R. Bone marrow mesenchymal stem cells repair spinal cord ischemia/reperfusion injury by promoting axonal growth and anti-autophagy. Neural regeneration research. 9(18):1665-71. 2014.