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Product Name
Human IFI30 (His Tag) recombinant protein
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Description
Lysosomal thiol reductase that can reduce protein disulfide bonds. May facilitate the complete unfolding of proteins destined for lysosomal degradation. Plays an important role in antigen processing. Facilitates the generation of MHC class II-restricted epitodes from disulfide bond-containing antigen by the endocytic reduction of disulfide bonds (By similarity). Facilitates also MHC class I-restricted recognition of exogenous antigens containing disulfide bonds by CD8+ T-cells or crosspresentation (By similarity).
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Protein name
Gamma-interferon-inducible lysosomal thiol reductase
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Protein short names
LEGUMATURAIN; MGC32056; LYSOSOMAL THIO REDUCTASE IP30; GAMMA-INTERFERON-INDUCIBLE PROTEIN IP-30; IP30; INTERFERON GAMMA-INDUCIBLE PROTEIN 30 PREPROPROTEIN; IFI-30; LYSOSOMAL THIOL REDUCTASE IP30; GAMMA-INTERFERON-INDUCIBLE LYSOSOMAL THIOL REDUCTASE; GILT
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Uniprot ID
P13284
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Gene Name
IFI30; GILT; IP30
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human IFI30 (P13284) (Met1-Lys243) with a C-terminal polyhistidine tag was expressed.
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Protein Species
Human
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Molecular weight
The recombinant human IFI30 is a disulfide-linked homodimer. The reduced monomer comprises 217 amino acids and has a predicted molecular mass of 24.7 kDa. The apparent molecular mass of the protein is approximately 31-34 kDa in SDS-PAGE under reducing conditions.
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Purity
> 96 % as determined by SDS-PAGE
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Validations
Human IFI30 Protein (His Tag) SDS-PAGE
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